Micky van de Ven Brace Ends Everton's Run at Brand New Home Ground
The Dutch defender emerged as the first backline player to score twice in a Premier League match for Spurs since the Belgian defender in spring 2013.
Match summary
Micky Van de Ven nods into the net two times in opening period
The home side's Jake O'Brien has goal disallowed after video check
Pape Matar Sarr nets final goal in dying moments
This loss is Everton's first at Hill Dickinson Stadium
The Tottenham defender scored twice as Tottenham prolonged their winning streak in away games in the top division and handed Everton their initial loss at Hill Dickinson Stadium.
Everton were undefeated in their five previous fixtures at their new ground at Bramley-Moore Dock, having left their historic home behind after 133 years at the conclusion of last season.
But Tottenham's leader the Dutchman struck twice from corners in the first half to put their strong form at jeopardy, and they were failed to turn it around before Pape Matar Sarr - assisted by ex-Everton forward the Brazilian - headed home a third to put the game to bed.
The Everton defender thought he had equalized the scores five minutes after Van de Ven's opener, glancing a bullet header past the Spurs keeper from an Everton corner.
Beto, meanwhile, failed to convert a handful of chances, while Vicario made a series of excellent stops to guarantee the London club went five matches on the road without defeat in the Premier League.
But the video assistant referee stepped in, instructing Craig Pawson to review the score on the screen and the referee ruled that Jack Grealish and Iliman Ndiaye were in offside positions and had interfered with the Spurs keeper.
The win elevates Thomas Frank's side into third place in the division, five points off north London rivals and leaders the Gunners.
Everton remain 14th and are six points ahead of the drop zone.
Tottenham analysis: Van de Ven fulfils duties at both ends of the field
After a uninspiring midweek performance in the European competition against the French side, where they mustered a only two shots on goal, the manager chose the French striker in attack instead of former Toffees player the Brazilian.
The summer signing was unable to make much of an impact before being substituted for Richarlison after an hour on the pitch, but it turns out he wasn't needed in the final outcome.
Defender the Dutchman transformed into an offensive threat to be feared.
Tottenham's first goal came from a well-worked set-piece play, with Rodrigo Bentancur directing the ball back across the face of goal for an unmarked Van de Ven to head home.
And the captain - filling in as captain in Cristian Romero's unavailability - notched his second in first-half stoppage time as he rose above the England keeper to head home.
The Dutchman was equally impressive in defensive duties, combining well with his defensive colleague as the duo handled superbly with the 34 crosses thrown their way by the opposition.
Toffees breakdown: Toffees missing striker's instinct
Everton's new home had been a happy hunting ground, but it appears the freshness may have worn off slightly and supporters headed to the exits after Sarr's third for Tottenham.
The break in Everton's winning streak at home will not be a massive concern for David Moyes, but their striker situation are.
Beto and Thierno Barry - the Everton's two recognised centre-forwards - had netted only one league goal between them before Sunday's outing.
And they were failed to contribute to that miserable tally on a damp and dreary evening on in Liverpool.
The striker's form was summed up when he chose to bicycle-kick a golden opportunity from close range, despite having space and opportunity to readjust for a simpler shot that would have challenged the keeper.
The substitute, too, was unable to make an impact after replacing Beto in the second half.
It was not for a lack of opportunity. The majority of the home side's attacks came through the winger and the forward, who relentlessly delivered dangerous crosses into the Tottenham penalty area.
What next for both teams?
The Toffees: Moyes' men head to the Stadium of Light in the Premier League on Monday, 3 November at 8 PM.
Spurs: The London club travel to Newcastle's ground on late October for their fourth-round League Cup tie against the Magpies.